• Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling 

      Dodig-Crnković, Tea; Hong, Mun-Gwan; Engel Thomas, Cecilia; Häussler, Ragna S.; Bendes, Annika; Dale, Matilda; Edfors, Fredrik; Forsström, Björn; Magnusson, Patrik K.E.; Schuppe-Koistinen, Ina; Odeberg, Jacob Olof; Fagerberg, Linn; Gummesson, Anders; Bergström, Göran; Mathias, Uhlén; Schwenk, Jochen M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-03)
      Background: Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less elaborate.<p> <p>Methods: To provide insights into the longitudinal protein signatures of well-being, we ...
    • Predictive value for cardiovascular events of common carotid intima media thickness and its rate of change in individuals at high cardiovascular risk - Results from the PROG-IMT collaboration 

      Lorenz, Matthias W.; Gao, Lu; Ziegelbauer, Kathrin; Norata, Giuseppe Danilo; Empana, Jean Philippe; Schmidtmann, Irene; Lin, Hung-Ju; McLachlan, Stela; Bokemark, Lena; Ronkainen, Kimmo; Amato, Mauro; Schminke, Ulf; Srinivasan, Sathanur R.; Lind, Lars; Okazaki, Shuhei; Stehouwer, Coen D.A.; Willeit, Peter; Polak, Joseph F.; Steinmetz, Helmuth; Sander, Dirk; Poppert, Holger; Desvarieux, Moise; Ikram, M. Arfan; Johnsen, Stein Harald; Staub, Daniel; Sirtori, Cesare R.; Iglseder, Bernhard; Beloqui, Oscar; Engström, Gunnar; Friera, Alfonso; Rozza, Francesco; Xie, Wuxiang; Parraga, Grace; Grigore, Liliana; Plichart, Matthieu; Blankenberg, Stefan; Su, Ta-Chen; Schmidt, Caroline; Tuomainen, Tomi-Pekka; Veglia, Fabrizio; Völzke, Henry; Nijpels, Giel; Willeit, Johann; Sacco, Ralph L.; Franco, Oscar H.; Uthoff, Heiko; Hedblad, Bo; Suarez, Carmen; Izzo, Raffaele; Zhao, Dong; Wannarong, Thapat; Catapano, Alberico; Ducimetiere, Pierre; Espinola-Klein, Christine; Chien, Kuo-Liong; Price, Jackie F.; Bergström, Göran; Kauhanen, Jussi; Tremoli, Elena; Dörr, Marcus; Berenson, Gerald; Kitagawa, Kazuo; Dekker, Jacqueline M.; Kiechl, Stefan; Sitzer, Matthias; Bickel, Horst; Rundek, Tatjana; Hofman, Albert; Mathiesen, Ellisiv B.; Castelnuovo, Samuela; Landecho, Manuel F.; Rosvall, Maria; Gabriel, Rafael; de Luca, Nicola; Liu, Jing; Baldassarre, Damiano; Kavousi, Maryam; de Groot, Eric; Bots, Michiel L.; Yanez, David N.; Thompson, Simon G. (Journal article; Peer reviewed; Tidsskriftartikkel, 2018-04-12)
      <b>Aims</b><br> Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk.<br> <b>Methods and results</b><br> From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts ...
    • Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium 

      Bahls, Martin; Lorenz, Matthias W.; Dörr, Marcus; Gao, Lu; Kitagawa, Kazuo; Tuomainen, Tomi-Pekka; Agewall, Stefan; Berenson, Gerald; Catapano, Alberico L.; Norata, Guiseppe D.; Bots, Michiel L.; van Gilst, Wiek; Asselbergs, Folkert W.; Brouwers, Frank P.; Uthoff, Heiko; Sander, Dirk; Poppert, Holger; Hecht Olsen, Michael; Empana, Jean Philippe; Schminke, Ulf; Baldassarre, Damiano; Veglia, Fabrizio; Franco, Oscar H.; Kavousi, Maryam; de Groot, Eric; Mathiesen, Ellisiv B.; Grigore, Liliana; Polak, Joseph F.; Rundek, Tatjana; Stehouwer, Coen D.A.; Skilton, Michael R.; Hatzitolios, Apostolos I.; Savopoulos, Christos; Ntaios, George; Plichart, Matthieu; McLachlan, Stela; Lind, Lars; Willeit, Peter; Steinmetz, Helmuth; Desvarieux, Moise; Ikram, M. Arfan; Johnsen, Stein Harald; Schmidt, Caroline; Willeit, Johann; Ducimetière, Pierre; Price, Jackie F.; Bergström, Göran; Kauhanen, Jussi; Kiechl, Stefan; Sitzer, Matthias; Bickel, Horst; Sacco, Ralph L.; Hofman, Albert; Völzke, Henry; Thompson, Simon G. (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-10-16)
      <i>Aims</i> - Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk factors is unclear.<p> <p><i>Methods and results</i> - An individual participant meta-analysis was used to associate the annualised progression of systolic ...